The application of
technology to dermo-cosmetics
The BENEFITS I will obtain by adding active ingredients encapsulated by INdermal to my formulations
- Much more efficient products as they can deliver up to twelve times as more active ingredient to the target layer of the skin
- Commercial advantage over those products with non-encapsulated active ingredients
- Easily achieved stability when handling traditionally unstable or sensitive active ingredients
- Improved cosmeticity and organoleptic properties of the products
- Formulated products on innovative foundationswhich harness the solubilizing properties of the nanoviscles
- Reduced costs by improving the efficiency of high cost active ingredients
The problems I will SOLVE by using this technology
- Degradation of the active ingredients by light, oxidation…
- Interactions between the active ingredient and the ingredients in the formula
- Colouration of the formula by active ingredients with high pigmentation.
- Client rejection due to the overly intense odours of certain molecules
- Skin intolerances through the use of other irritating penetration enhancers (alcohol…)
Concentration up to 15 times bigger than other standard liposome products
SMART DELIVERY SYSTEM
Specific and optimum design of each system to conduct and deliver the active ingredient in a controlled manner to the cosmetic target of the skin (corneal layer, deep epidermis, capillary fibre or hair follicle) thereby maximising its efficiency.
COMPLETE PROTECTION OF THE ACTIVE INGREDIENT
This advanced technology in high efficiency encapsulation systems protects the active ingredient from oxidation, degradations, interactions and solar radiation thereby perfectly preserving its properties up to the point of delivery to the target skin structure.
High resistance to temperature (max 78ºc) and shear stress (up to 20,000 rpm). Wide pH range (3-11). Expiry: 12 m. Made on demand to guarantee maximum quality and durability.
A similar composition to the epidermis cell membranes including lipids and phospholipids of natural origin, high bioavailability and pharmaceutical grade, analogous to those present in the epidermis and hair.
HIGH STRENGTH HYDRATION AND RESTORATION
Thanks to its high concentration of basic phospholipids it repairs damaged hair, restores resistance and protection functions and reduces the trans epidermal water loss. The ceramides incorporated in some of the systems reinforce these properties including in the hair.
We offer you
Penetration and delivery studies
We perform “ex vivo” skin penetration tests as part of the verification process of the ideal functionality of all the products, determining the amount of active ingredient delivered to each cutaneous stratum, comparative with the natural diffusion of non-encapsulated active ingredient
Fluorescence checks by confocal microscopy
Specific studies of each delivery system have been carried out developing fluorescent nanovesicles which are tracked by confocal microscopy to study their specific accumulation in the target areas.
We carry out efficiency tests using human skin explants to simulate real life situations of penetration and cosmetic activity.
By way of example we hereunder show some of the results obtained:
DDS- Retinol anti-wrinkle capacity
With an equal concentration of Retinol, the DDS-RETINOL product is 4.5 times more efficient than free Retinol, recovering 90% of the collagen 9 days after the commencement of treatment.
DDS- Kojic depigmentation efficiency
With an equal concentration of Kojic acid, the DDS-KOJIC product reduces the melanin levels similar to those in the un-irradiated controls.
DDS-KOJIC produces a prompt action; after only three applications and by the fifth day a strong depigmentation action was observed. According to other published studies, the free active ingredient required more time to produce results.
With each production all of our products are subjected to an exhaustive characterisation analysis, something , pero unparalleled in the cosmetics industry but fundamental in order to guarantee the quality and comparable features of the clinical products. .
In order to certify the perfect condition of the nanovesicles after their addition into the final product, a characterisation by NTA could be carried out to check the main nanovesicle parameters such as size, distribution and concentration.
- Average Size
- Size distribution (PDI)
- Encapsulation efficiency of the active ingredient
- Liposome concentration
A DELIVERY SYSTEM FOR EACH COSMETIC TARGET
DEEP DELIVERY SYSTEM
CORNEUM DELIVERY SYSTEM (NEW)
HAIR DELIVERY SYSTEM
FOLLICULAR DELIVERY SYSTEM (NEW)
TRY US OUT!
Incorporate encapsulated active ingredients into your formulations. Surprise your customers and stand out from your competitors by taking your products to the next level in efficiency.
NANOVEX BIOTECHNOLOGIES S.L.
Parque Tecnológico de Asturias. CEEI.
33428 LLANERA, ASTURIAS. SPAIN
Tel: +34 985 980 605