The application of

DRUG DELIVERY

technology to dermo-cosmetics

By way of contrast to the traditional liposomes used in cosmetics which are formulated with soy lecithin and manufactured with basic methodology, INdermal offers a new generation of nanovesicles which are custom designed to the active ingredient they contain and to the cosmetic target of the skin where they are to be delivered.

The BENEFITS I will obtain by adding active ingredients encapsulated by INdermal to my formulations

Much more efficient products as they can deliver up to twelve times as more active ingredient to the target layer of the skin
Commercial advantage over those products with non-encapsulated active ingredients
Easily achieved stability when handling traditionally unstable or sensitive active ingredients
Improved cosmeticity and organoleptic properties of the products
Formulated products on innovative foundationswhich harness the solubilizing properties of the nanoviscles
Reduced costs by improving the efficiency of high cost active ingredients

The problems I will SOLVE by using this technology

Degradation of the active ingredients by light, oxidation…
Interactions between the active ingredient and the ingredients in the formula
Colouration of the formula by active ingredients with high pigmentation.
Client rejection due to the overly intense odours of certain molecules
Skin intolerances through the use of other irritating penetration enhancers (alcohol…)

CONTROLLED

DELIVERY

150-300nm

CERTIFICATE

SIZE

No GMO
No BSE
Without parabens

Concentration up to 15 times bigger than other standard liposome products

SMART DELIVERY SYSTEM

Specific and optimum design of each system to conduct and deliver the active ingredient in a controlled manner to the cosmetic target of the skin (corneal layer, deep epidermis, capillary fibre or hair follicle) thereby maximising its efficiency.

COMPLETE PROTECTION OF THE ACTIVE INGREDIENT

This advanced technology in high efficiency encapsulation systems protects the active ingredient from oxidation, degradations, interactions and solar radiation thereby perfectly preserving its properties up to the point of delivery to the target skin structure.

MAXIMUM STABILITY

High resistance to temperature (max 78ºc) and shear stress (up to 20,000 rpm). Wide pH range (3-11). Expiry: 12 m. Made on demand to guarantee maximum quality and durability.

BIOMIMETIC COMPOSITION

A similar composition to the epidermis cell membranes including lipids and phospholipids of natural origin, high bioavailability and pharmaceutical grade, analogous to those present in the epidermis and hair.

HIGH STRENGTH HYDRATION AND RESTORATION

Thanks to its high concentration of basic phospholipids it repairs damaged hair, restores resistance and protection functions and reduces the trans epidermal water loss. The ceramides incorporated in some of the systems reinforce these properties including in the hair.

We offer you
QUALITY &
RELIABILITY

Penetration and delivery studies

We perform “ex vivo” skin penetration tests as part of the verification process of the ideal functionality of all the products, determining the amount of active ingredient delivered to each cutaneous stratum, comparative with the natural diffusion of non-encapsulated active ingredient

Fluorescence checks by confocal microscopy

Specific studies of each delivery system have been carried out developing fluorescent nanovesicles which are tracked by confocal microscopy to study their specific accumulation in the target areas.

Efficiency tests

We carry out efficiency tests using human skin explants to simulate real life situations of penetration and cosmetic activity.

By way of example we hereunder show some of the results obtained:

DDS- Retinol anti-wrinkle capacity

(Collagen Analysis)

CONCLUSIONS:

With an equal concentration of Retinol, the DDS-RETINOL product is 4.5 times more efficient than free Retinol, recovering 90% of the collagen 9 days after the commencement of treatment.

DDS- Kojic depigmentation efficiency

(Melanin Analysis)

CONCLUSIONS:

With an equal concentration of Kojic acid, the DDS-KOJIC product reduces the melanin levels similar to those in the un-irradiated controls.

DDS-KOJIC produces a prompt action; after only three applications and by the fifth day a strong depigmentation action was observed. According to other published studies, the free active ingredient required more time to produce results.

Complete characterisation

With each production all of our products are subjected to an exhaustive characterisation analysis, something , pero unparalleled in the cosmetics industry but fundamental in order to guarantee the quality and comparable features of the clinical products. .

In order to certify the perfect condition of the nanovesicles after their addition into the final product, a characterisation by NTA could be carried out to check the main nanovesicle parameters such as size, distribution and concentration.