Vegan DDS Retinol

Deep Delivery Nanovesicles
with 3% Retinyl Palmitate






Up to 15 times greater concentration than other concentration than other

150-300 nm


Biodegradable **

Very good skin
compatibility ***

* According to ISO 16128.

** According to OECD criteria. The biodegradability of this product is calculated from the accumulated biodegradability data of the individual constituents used in the manufacture of this product.

*** According to patch test



Skin care

Skin care

Body care


boosts collagen
(according to efficacy study)


boosts elastin
(according to efficacy study)

Vegan CDS Delivery System

DDS or Deep delivery system is composed of mainly phospholipids and membrane stabilizers. It contains the right amount of penetration enhancers and edge activators that help the system reach the desired cells.

Benefits of the encapsulation Vegan DDS

Protects active against degradation

Maximum delivery of the active ingredient into the deep skin levels

Gradual delivery for longer lasting effect

Increases the bioavailability of the active ingredient

Avoids colour changes in the cosmetic product

Biomimetic nanovesicle with high moisturising and restorative action

Active encapsulated

Retinyl Palmitate, an ester of vitamin A, is a reliable source of vitamin A for the skin. Upon reaching deep skin levels, it converts to Retinol, Retinal, and finally to Retinoic Acid. It stimulates the production of hyaluronic acid, collagen, and elastin, making it a potent anti-aging ingredient. It accelerates cell regeneration, improves skin texture, minimizes pore size, and is commonly found in acne treatment products due to its sebum-regulating ability. Furthermore, it suppresses melanin production, reducing skin blemishes.

active ingredients properties

Stimulates the production of collagen, elastin and hyaluronic acid

Acts as an antioxidant and cell regenerator

Minimises pore size and prevents hyperkeratinisation

Regulates the production of sebum

Represses melanogenesis

Proven efficacy

Gel with 5% Vegan DDS Retinol vs gel with same concentration of free retinyl palmitate

Human organotypic skin explant cultures (hOSECs)

To replicate skin aging, a corticoid cocktail was administered to the growing skin medium

Topical application over a period of 7 non-consecutive days

x3 more effective
than FREE RETINYL PALMITATE in collagen recovery
x5.6 more effective
than FREE RETINYL PALMITATE in elastin recovery

Sustained penetration

The sustainable and progressive delivery study over 24 h of the Vegan DDS system

Using a model analyte (ethyl ascorbic acid)

Human skin explants

Application of the sample containing ethyl ascorbic acid encapsulated into Vegan DDS liposomes

Epidermal concentration of the active at different times

Determined using HPLC-RC after extraction from the human epidermis

DDS by INdermal nanovesicles are ideal for the cosmetic application of active ingredients which require a progressive and sustained delivery over time in the epidermal layer

Targeted delivery

Fluorescent Vegan DDS liposomes with rhodamine-labelled phospholipids (18:1 PE CF) in the membrane of the liposomes can be seen in red.

The skin was dyed with DAPI, that stains cellular nuclei with an emission maximum at 461 nm in blue.

Specific release of the active ingredient into the epidermal layer of the skin

Download delivery study

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