The use of these superficial delivery systems substantially increases the concentration of the active ingredient in the stratum corneum, minimalizing penetration at deeper levels. This is particularly useful in avoiding unwanted effects that can be caused at this level, for example when using active ingredients with a high irritant capability.

The Corneum Delivery systems are especially useful for the encapsulation of alpha-hydroxy acids as they facilitate a very low pH level in the nanovesicles, irrespective of the average pH where they are made.

As a consequence, practically all of the acid concentration in the nanovesicle remains unseparated until its release in the stratum corneum. This facilitates a reduction in the necessary dosage of AHA and the use of more physiologically formulated pHs.

The phospholipids and ceramides which compose the nanovesicle quickly repair any damage caused by the AHA, recuperating the skin barrier and notably increasing the tolerance level.