CORNEUM DELIVERY SYSTEM

CORNEUM DELIVERY SYSTEM

The active ingredients encapsulated in the “Corneum Delivery” systems are delivered specifically to the superficial layers of the epidermis – the stratum corneum – for a more intense and precise effect at this level.

The use of these superficial delivery systems substantially increases the concentration of the active ingredient in the stratum corneum, minimalizing penetration at deeper levels. This is particularly useful in avoiding unwanted effects that can be caused at this level, for example when using active ingredients with a high irritant capability.

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Ideal for the formulation of products such as

Renovators

Peeling treatments for sensitive skins

Moisturisers

Anti-acne agents

Restoratives

Anti-irritants

IMPROVE THE EFFICIENCY OF THE COSMETIC ACTIVE ingredients by UP TO 20 TIMES, through selective delivery in the target area.

SOLVE ORGANOLEPTIC PROBLEMS by masking the smells and colours of the ingredients in a rapid, enduring and scalable manner.

Simplify the formulation process by PROTECTING THE ACTIVE ingredient from oxidation, light degradation and interaction with other ingredients.

Comfortable and easy to incorporate owing to their HIGH LEVELS OF STABILITY AND COMPATIBILITY with all types of cosmetic forms.

LOW IRRITATION due to sustained delivery and control over pH.

Fluorescent Vegan DDS liposomes with rhodamine-labelled phospholipids (18:1 PE CF) in the membrane of the liposomes can be seen in red.

The skin was dyed with DAPI, that stains cellular nuclei with an emission maximum at 461 nm in blue.

5-(6)-carboxyfluorescein
VS
5-(6)-carboxyfluorescein encapsulated in Vegan DDS nanovesicles

Corneal layer
0.9 µg/cm2

Basal layer
3,3 µg/cm2

x 3.11

x 0.95

Corneal layer
2.8 µg/cm2

Basal layer
2.2 µg/cm2

5-(6)-carboxyfluorescein

The determinations of the analyte model (5-(6)-carboxyfluorescein) reveal an amount three times greater in the corneal layer in the samples tested with CDS nanovesicles.

5-(6)-carboxyfluorescein encapsulated in Vegan DDS nanovesicles

Corneal layer 0.9 µg/cm2

x 3.11

Corneal layer 2.8 µg/cm2

Basal layer 2,3 µg/cm2

x 0.95

Basal layer 2.2 µg/cm2

5-(6)-carboxyfluorescein
The determinations of the analyte model (5-(6)-carboxyfluorescein) reveal an amount three times greater in the corneal layer in the samples tested with CDS nanovesicles.
5-(6)-carboxyfluorescein encapsulated in Vegan DDS nanovesicles

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