Deep Delivery Nanovesicles
with Epidermal Growth Factor (EGF) 0.0025 ppm






Up to 15 times greater concentration than other

150-300 nm


Biodegradable **

Very good skin
compatibility ***

* According to ISO 16128.

** According to OECD criteria. The biodegradability of this product is calculated from the accumulated biodegradability data of the individual constituents used in the manufacture of this product.

*** According to patch test



Skin care

Body care

x18.5 more efective

(according to efficacy study)

x18.5 more efective

(according to efficacy study)


(according to efficacy study)

Vegan DDS Delivery System

DDS or Deep delivery system is composed of mainly phospholipids and membrane stabilizers.

It contains the right amount of penetration enhancers and edge activators that help the system reach the desired cells.

Benefits of the encapsulation Vegan DDS

Protects active against degradation

Maximum delivery of the active ingredient into the deep skin levels

Gradual delivery for longer lasting effect

Increases the bioavailability of the active ingredient

Avoids colour changes in the cosmetic product

Biomimetic nanovesicle with high moisturising and restorative action

Active encapsulated

The Epidemic Growth Factor (EGF or Oligopeptide-1) is a peptide naturally produced in the body, promoting skin repair, growth, and the formation of new epithelial cells.

As the body ages, EGF production decreases. EGF-containing products are used to prevent and reverse these effects.

However, EGF is sensitive to external factors and easily loses its properties. Additionally, its ability to penetrate the skin is limited.

The Vegan DDS system is a beneficial protective and transport system for EGF, addressing these limitations.

active ingredients properties

Regenerates and repairs the skin

Prevents wrinkling and other signs of aging

Reduces existing wrinkles and expression lines

Increases the production of collagen, elastin and hyaluronic acid, strengthening and tightening the skin

Balances the biological process in the skin

Proven efficacy ex vivo

Gel with 10% Vegan DDS EGF vs gel with same concentration of free EGF

Human organotypic skin explant cultures (hOSECs)

To mimic skin photo-aging, sun-like light irradiation (5 J/cm2) was applied daily to the hOSEC Total of 7 non-consecutive applications

x11 more effective
than FREE EGF in collagen recovery
x6 more effective
than FREE EGF in elastin recovery
Masson’s Trichrome stain 50x magnification.
Elastic fibers (collagen) stained in green
Masson’s Trichrome stain 200x magnification.
Elastic fibers (collagen) stained in green

Sustained penetration

The sustainable and progressive delivery study over 24 h of the Vegan DDS system

Using a model analyte (ethyl ascorbic acid)

Human skin explants

Application of the sample containing ethyl ascorbic acid encapsulated into Vegan DDS liposomes

Epidermal concentration of the active at different times

Determined using HPLC-RC after extraction from the human epidermis

DDS by INdermal nanovesicles are ideal for the cosmetic application of active ingredients which require a progressive and sustained delivery over time in the epidermal layer

Targeted delivery

Fluorescent Vegan DDS liposomes with rhodamine-labelled phospholipids (18:1 PE CF) in the membrane of the liposomes can be seen in red.

The skin was dyed with DAPI, that stains cellular nuclei with an emission maximum at 461 nm in blue.

Specific release of the active ingredient into the epidermal layer of the skin

Download delivery study