Vegan DDS Enoxolone

Deep Delivery Nanovesicles
with 0.5% Glycyrrhetic Acid

Img_DDS

1-10%

RECOMMENDED DOSAGE

98.05%

NATURAL ORIGIN *

Up to 15 times greater concentration than other

150-300 nm

AVERAGE SIZE

Readily
Biodegradable **

Very good skin
compatibility ***

* According to ISO 16128.

** According to OECD criteria. The biodegradability of this product is calculated from the accumulated biodegradability data of the individual constituents used in the manufacture of this product.

*** According to patch test

Certifications

APPLICATIONS

Skin care
Anti-aging

Skin care
Balance

Body care

-114,32 %

levels of IL-1α
(according to efficacy study)

-44.26%

levels of IL-6
(according to efficacy study)

-24.19%

levels of IL-8
(according to efficacy study)

Vegan DDS Delivery System

DDS or Deep delivery system is composed of mainly phospholipids and membrane stabilizers.

It contains the right amount of penetration enhancers and edge activators that help the system reach the desired cells.

Benefits of the encapsulation Vegan DDS

Protects active against degradation

Maximum delivery of the active ingredient into the deep skin levels

Gradual delivery for longer lasting effect

Increases the bioavailability of the active ingredient

Avoids colour changes in the cosmetic product

Biomimetic nanovesicle with high moisturising and restorative action

Active encapsulated

Enoxolone, derived from licorice root, is extensively used in Chinese natural medicine for its anti-inflammatory, antioxidant, and antimicrobial properties.

It inhibits the enzyme 11-hydroxysteroid dehydrogenase, reducing inflammation and offering benefits like preventing DNA fragmentation, itchiness in dermatitis, and promoting skin tone evenness.

Enoxolone proves to be a superior alternative to hydrocortisone in treating conditions such as eczema, dermatitis, psoriasis, acne, sunburn, and hyperpigmentation.

active ingredients properties

Anti-inflamatory properties that can help to soothe and calm irritated skin

Skin brightening, helping to reduce the appearance of age spots

Anti-aging, helping to protect the skin from free radical damage

Moisturizing the skin making it softer and smoother

Proven efficacy ex vivo

Gel with 5% Vegan DDS Enoxolone vs gel with same concentration of free Enoxolone

Human organotypic skin explant cultures (hOSECs)

Lipopolysaccharide (LPS) of E. coli was applied to produce an inflammatory reaction

-114 % reduction
of inflammation regarding IL-1α
-44 % reduction
of inflammation regarding IL-6
x30 more effective
than FREE ACTIVE in IL-8 reduction

Sustained penetration

The sustainable and progressive delivery study over 24 h of the Vegan DDS system

Using a model analyte (ethyl ascorbic acid)

Human skin explants

Application of the sample containing ethyl ascorbic acid encapsulated into Vegan DDS liposomes

Epidermal concentration of the active at different times

Determined using HPLC-RC after extraction from the human epidermis

DDS by INdermal nanovesicles are ideal for the cosmetic application of active ingredients which require a progressive and sustained delivery over time in the epidermal layer

Targeted delivery

Fluorescent Vegan DDS liposomes with rhodamine-labelled phospholipids (18:1 PE CF) in the membrane of the liposomes can be seen in red.

The skin was dyed with DAPI, that stains cellular nuclei with an emission maximum at 461 nm in blue.

Specific release of the active ingredient into the epidermal layer of the skin

Download delivery study