Vegan DDS Pure Retinal

Deep Delivery Nanovesicles
with 1% Retinal

Img_DDS

1-10%

RECOMMENDED DOSAGE

98.59%

NATURAL ORIGIN *

Up to 15 times greater concentration than other

150-300 nm

AVERAGE SIZE

Readily
Biodegradable **

Very good skin
compatibility ***

* According to ISO 16128.

** According to OECD criteria. The biodegradability of this product is calculated from the accumulated biodegradability data of the individual constituents used in the manufacture of this product.

*** According to patch test

Certifications

APPLICATIONS

Skin care
Anti-aging

Skin care
Balance

Body care

123,61%

recovery of collagen levels
(according to efficacy study)

111,18%

recovery of elastin levels
(according to efficacy study)

High molecular stability

Vegan DDS Delivery System

DDS or Deep delivery system is composed of mainly phospholipids and membrane stabilizers.

It contains the right amount of penetration enhancers and edge activators that help the system reach the desired cells.

Benefits of the encapsulation Vegan DDS

Protects active against degradation

Maximum delivery of the active ingredient into the deep skin levels

Gradual delivery for longer lasting effect

Increases the bioavailability of the active ingredient

Avoids colour changes in the cosmetic product

Biomimetic nanovesicle with high moisturising and restorative action

Active encapsulated

Retinaldehyde or Retinal (RETINAL) is a precursor of retinoic acid, an intermediate metabolite produced in the transformation of retinol into retinoic acid in human keratinocytes.

Retinal is metabolised to retinoic acid in the skin, as well as to retinol and retinyl esters (which usually diminish during photoaging) and are indicated for use in the treatment of aging signs that require quicker results than those offered by other retinoids used in cosmetics.

active ingredients properties

Stimulates the production of collagen, elastin and hyaluronic acid

Acts as an antioxidant and cell regenerator

Minimises pore size and prevents hyperkeratinisation

Reduces signs of acne

Modulates the vascular endothelium growth factor

Proven efficacy

Gel with 5% Vegan DDS Pure Retinal vs gel with same concentration of free retinal

Human organotypic skin explant cultures (hOSECs)

To replicate skin aging, a corticoid cocktail was administered to the growing skin medium

Topical application over a period of 9 non-consecutive days

Vegan DDS-Pure Retinal (5%) can increase collagen lev- els up to 3,7 times more than the free Retinal (0,05%) achieving an increase of collagen levels by 123,61% with respect to the healthy control, while the free reti- nal increases collagen levels by 33,08%.

Vegan DDS-Pure Retinal (5%) can increase elastin lev- els up to 3,72 times more than the free Retinal (0,05%) achieving an increase of elastin levels by 111,18% with respect to the healthy control, while the free retinal in- creases elastin levels by 15,36%.

Results of stability test

Vegan DDS Pure Retinal was analysed in terms of stability during 4 weeks at 40oC. Results are represented in the following graphic

Sustained penetration

The sustainable and progressive delivery study over 24 h of the Vegan DDS system

Using a model analyte (ethyl ascorbic acid)

Human skin explants

Application of the sample containing ethyl ascorbic acid encapsulated into Vegan DDS liposomes

Epidermal concentration of the active at different times

Determined using HPLC-RC after extraction from the human epidermis

DDS by INdermal nanovesicles are ideal for the cosmetic application of active ingredients which require a progressive and sustained delivery over time in the epidermal layer

Targeted delivery

Fluorescent Vegan DDS liposomes with rhodamine-labelled phospholipids (18:1 PE CF) in the membrane of the liposomes can be seen in red.

The skin was dyed with DAPI, that stains cellular nuclei with an emission maximum at 461 nm in blue.

Specific release of the active ingredient into the epidermal layer of the skin

Download delivery study