Vegan DDS True Retinol

Deep Delivery Nanovesicles
with 2% Pure Retinol






Up to 15 times greater concentration than other concentration than other

150-300 nm


Biodegradable **

Very good skin
compatibility ***

* According to ISO 16128.

** According to OECD criteria. The biodegradability of this product is calculated from the accumulated biodegradability data of the individual constituents used in the manufacture of this product.

*** According to patch test



Skin care

Skin care

Body care

x18.5 more efective

(according to efficacy study)

x18.5 more efective

recovery of elastin levels
(according to efficacy study)


(according to efficacy study)

Vegan DDS Delivery System

DDS or Deep delivery system is composed of mainly phospholipids and membrane stabilizers.

It contains the right amount of penetration enhancers and edge activators that help the system reach the desired cells.

Benefits of the encapsulation Vegan DDS

Protects active against degradation

Maximum delivery of the active ingredient into the deep skin levels

Gradual delivery for longer lasting effect

Increases the bioavailability of the active ingredient

Avoids colour changes in the cosmetic product

Biomimetic nanovesicle with high moisturising and restorative action

Active encapsulated

Retinol is a soughtafter active ingredient in cosmetics for its antiaging properties and skin enhancement benefits.

Retinol promotes skin cell production, facilitating exfoliation and boosting collagen synthesis.

These actions contribute to di- minishing fine lines, wrinkles, and preventing clogged pores.

The versatile nature of retinol makes it effective in treating acne, acne scars, melasma spots, and expression lines.

Vegan DDS True Retinol mentioned do not contain BHT or BHA, with tocopheryl acetate serving as the sole antioxidant.

active ingredients properties

The best and most demanded anti-ageing active

Reduces the appearance of wrinkles and pore size

Increases firmness

Improves skin textures

Proven efficacy ex vivO

Gel with 5% Vegan DDS True Retinol vs gel with same concentration of free Retinol vs gel with competitor’s en- capsulated retinol for same final concentration (0.1% retinol)

Human organotypic skin explant cultures (hOSECs)

To mimic skin photo-aging, sun-like light irradiation (5 J/cm2) was applied daily to the hOSEC

Total of 7 non-consecutive applications

x18.5 more effective
than FREE RETINOL in collagen recovery
x1.8 more effective
than COMPETITOR in collagen recovery
x1.7 more effective
than FREE RETINOL in elastin recovery
x1.3 more effective
than COMPETITOR in elastin recovery

Proven efficacy IN vivo

Gel with 5% Vegan DDS True Retinol as the only active ingredient

30 volunteers of women between 35 and 60 years old whose skin is oily or combination skin and pigmented with signs of ageing

56 days of treatment

91% of volunteers

said that their general skin
appearance had improved

It makes my skin firmer

Improves the
appearance of my pores

Skin feels less oily

Notice fading of existing

My skin is softer

Skin more moisturized

Skin more restored and protected

Sustained penetration

The sustainable and progressive delivery study over 24 h of the Vegan DDS system

Using a model analyte (ethyl ascorbic acid)

Human skin explants

Application of the sample containing ethyl ascorbic acid encapsulated into Vegan DDS liposomes

Epidermal concentration of the active at different times

Determined using HPLC-RC after extraction from the human epidermis

DDS by INdermal nanovesicles are ideal for the cosmetic application of active ingredients which require a progressive and sustained delivery over time in the epidermal layer

Targeted delivery

Fluorescent Vegan DDS liposomes with rhodamine-labelled phospholipids (18:1 PE CF) in the membrane of the liposomes can be seen in red.

The skin was dyed with DAPI, that stains cellular nuclei with an emission maximum at 461 nm in blue.

Specific release of the active ingredient into the epidermal layer of the skin

Download delivery study